ncRNA name | VEGFA shRNA |
ncRNA Category | shRNA |
Disease name | retinopathy of prematurity (ROP) |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas |
Methods | shRNA injection, retinal imaging, ERG, OCT, immunohistochemistry |
Expression pattern | associated |
Functional description | Lectin-stained retinal flat mounts analyzed for areas of avascular/total retina (AVA) and intravitreal neovascular/total retina (IVNV) showed initial significantly reduced IVNV by L-VEGFAshRNA and L-VEGF164shRNA compared to control, luciferase-shRNA lentivirus, without late recurrence. |
PubMed ID | 29386650 |
Year | 2018 |
Title | Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms. |
Drug-related ncRNA | NA |
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